The book explores the fundamental human dignity and respect relating to HIV/AIDS positive people who have suffered scorn, isolation, discrimination and stigma in the society. The book suggests a God-honoring way to relate to God's image-bearers (imago-dei) who have HIV/AIDS or any disease that has similar stigma. It is out of that aspiration and anticipation of this book to plan and implement a teaching series to the church/organizations as Christian response to HIV/AIDS. The book goes a long way in providing teaching series and resources to garner that goal and objective to treat all people equally, with dignity and respect as God's image-bearers. This book is highly recommended to everyone, including Christian teachers, leaders and Ministers who desire to see the members of the society treated with dignity and respect as Dr. Sabelo Sam Gasela Mhlanga outlines all the fabric social issues patterning to HIV/AIDS that hang on the balance and pose a threat to the 21st generation.